Homeostatic capacity—a concept analogous to resilience, strength, buffer, robustness, antifragility, and antifrailty—is the efficiency of an autoregulatory system to maintain functional homeostasis against ubiquitous stressors and entropy. The interaction of homeostatic capacity and stressors determines health. We envision a model for healthy, functional longevity based on evaluating and improving homeostatic capacity.
Homeostasis is a relatively stable state of equilibrium. Homeostatic capacity (or allostatic capacity, buffering capacity, compensatory capacity, or autoregulatory capacity) is the efficiency of an autoregulatory system to maintain functional homeostasis. The interaction of homeostatic capacity and stressors determines health. We envision a model for healthy, functional longevity based on evaluating and improving homeostatic capacity.
Aging & Longevity Grand Challenge
As the inaugural challenge in its Grand Challenges in Health and
Medicine initiative, the National Academy of Medicine will seek to
transform the future of human aging and longevity by catalyzing
innovation and progress.
Human beings are living longer than ever before, thanks to dramatic
advances in medicine, public health, and economic and social progress. Exciting innovations in science and technology have potential to improve quality of life as we age — and even extend the lifespan. As the world’s aging population approaches a tipping point, accompanied by unsustainable health care costs and social burden, it has never been more urgent to support the next breakthroughs in healthy aging.
NASEM Health and Medicine Division – 10/19/2015
Joon Yun, M.D., Managing Partner and President, Palo Alto Investors, LLC; and Benefactor, Palo Alto Longevity Prize
Is Heart Rate Variability the best biomarker of the time to track our longevity? In this episode, we look at why HRV may be the best way to track how well you are aging and the bets being placed on it in Silicon Valley to drive innovation in anti-aging and longevity research.
Previously we’ve looked at using HRV for training and recovery, stress management, and tracking hormesis. If you are new to biohacking, HRV is an easy economical way to start tracking. All one needs is a heart rate strap and phone app.
On “Taking Stock” with Pimm Fox and Olivia Stern, Bloomberg TV 2013
Ethylene is a gaseous hydrocarbon with the molecular structure C2H4. It is commonly produced when hydrocarbons are exposed to oxidative stress, such as that found during lightning, volcanic eruptions, forest fires, and photochemical reactions on the ocean surface. Plants coopted ethylene biosynthesis during evolution to manage their response to oxidative stress from biotic and abiotic sources. Further exaptations of ethylene include modulation of plant life history events such as development, transformation, senescence, and death.
Due to a number of factors described below, humans may be subject to increasing ethylene exposure. The potential health consequences of ethylene exposure are not part of the public consciousness and warrant further exploration.